Well, first off I'd say nevermind the speaker wire length; you can buy or make extensions for just a few bucks, right? So it shouldn't be a big concern IMHO. In terms of filling a room though, if you're looking for PC speakers, you might look into the Bose Companion 3 or 5. If you're looking for a PA system, well... I'd need to know your budget to make a good recommendation.
