Little background information. Target OS : Dual boot Windows 10 (preferably)/Windows 8.1 with Cent OS 7.1 I have no experience in building a desktop till date except the videos of other guys building desktop on you-tube. This is my first attempt. I am open to all advices/options. I have chosen AMD based processor as I find economical compared to Intel processors. I have looked in mother board. I have prefer with 990FXA chip-set based mother board. I have chosen 24 inch LED Monitor Full HD (1980 × 1080). I have chosen AMD Radeon Rx300 series GPU. This is a one time investment. I don't plan to upgrade it for at-least 10 years except of refilling liquid cooling solution. Processor Selected : AMD FX-8350 Black Edition Vishera 8-Core 4.0GHz (4.2GHz Turbo) Socket AM3+ 125W FD8350FRHKBOX Desktop Processor Graphic Card Selected : MSI Radeon R9 390X R9 390X GAMING 8G LE 8GB 512-Bit GDDR5 HDCP Ready CrossFireX Support ATX Video Card OR MSI Radeon R9 390 R9 390 GAMING 8G 8GB 512-Bit GDDR5 PCI Express 3.0 HDCP Ready CrossFireX Support Video Card OR MSI Radeon R9 380 R9 380 GAMING 4G 4GB 256-Bit GDDR5 PCI Express 3.0 HDCP Ready CrossFireX Support ATX Video Card (2 Units crossfire enabled) Mother Board : MSI 990FXA-GAMING AM3+/ AM3 AMD 990FX & SB950 6 x SATA 6Gb/s 2 x USB 3.1 ATX AMD Motherboard OR ASUS SABERTOOTH 990FX R2.0 AM3+ AMD 990FX + SB950 8 x SATA 6Gb/s USB 3.0 ATX AMD Motherboard with UEFI BIOS RAM : 4 x Kingston FURY Memory - 4GB Module - DDR3 1866MHz CL10 DIMM Display : BenQ RL2455HM 24 inch LED Monitor Full HD (1980 × 1080) Hard Drive : WD BLACK SERIES WD2003FZEX 2TB 7200 RPM 64MB Cache SATA 6.0Gb/s 3.5" Internal Hard Drive I/O Ports : Enter E-2S PCI To 2 Serial ( RS-232 ) Port Cards Internal Optical Drive : Asus DRW-24D3ST/BLK/G/AS DVD Burner Internal Optical Drive Power Supply Unit : CORSAIR AX860i Digital ATX Power Supply — 860 Watt 80 PLUS® Platinum Certified Fully-Modular PSU (EU Plug) OR Cooler Master V1000 - Fully Modular 1000W 80 PLUS Gold PSU with Silencio FP Silent 135mm fan Liquid Cooling Kit : Corsair Hydro Series™ H100i GTX Extreme Performance Liquid CPU Cooler OR Cooler Master Nepton 240M RL-N24M-24PK-R1 All-in-One CPU Water Cooling System Chassis : Cooler Master HAF XB EVO Windowed Gaming Case OR Cooler Master Storm Trooper/Stryker Cabinet OR Graphite Series™ 780T Full-Tower PC Case OR Obsidian Series® 750D Airflow Edition Full Tower ATX Case I have the following question : The graphic card I have selected are PCI 3.0 based, however all the specified motherboards are PCI 2.0 based. Are PCI 3.0 based graphic card compatible/work with PCI 2.0 based motherboards? If yes what is the performance penalty it will suffer? Kindly suggest if their is an noticeable performance between R9 390X and R9 390. Also will it be advisable to get 2 Cross-Fire enabled R9 380 4 G.B. video Card or a single R9 390X/ R9 390 8 G.B. video card? Kindly advice me on motherboard. I am strongly inclined to MSI 990FXA-GAMING AM3+/ AM3 AMD 990FX & SB950 6 x SATA 6Gb/s 2 x USB 3.1 ATX AMD Motherboard. With regards to power supply unit I am having a feeling that CORSAIR AX860i Digital ATX Power Supply — 860 Watt 80 PLUS® Platinum Certified Fully-Modular PSU (EU Plug) will be adequate as per my calculation. I am getting power supply requirement of about 600Watts. Will their be a need currently unseen by me to have have a higher rating power supply. Also I wish to know if their will be compatibility issue if I get power supply of Corsair and cabinet form cooler master or vice versa. Kindly suggest most appropriate build with Windows 10 compatibility. I wish to know is it really worth investing in liquid cooling kit? I really am confused regarding which chassis and water cooling kit to pick. Information about newegg.com credibility is also welcomed. Also inform me if I am missing something. Any advice regarding better/economical build is welcomed. Their is a a lot of talk on Internet that a new Generation of CPU are going to be launched by AMD. Should I wait or its going to take a long time. I plan to stay on FX type CPU only no APU.