sorry did you try with each wire only e.g. only having the keyboard plugged in and messing around on the computer. Try a different mouse/speaker, make make sure the volume isnt too high in the setitngs.
I also have a Logitech MX revoultion mouse but not having any problems. I think If you can try another mouse/speaker that’d give you a better idea as to what might be causing the interference. As if you still get interference there something thats causing it.