This is kind of a tough one for all of us into this sort of thing I'm sure but do you're best to compile a list if you like. It's a bit to hard to rank them in my opinion so I'll just shout out some of my favs. They don't necessarily have to be weapons available to the player either. Gravity Gun from HL2 naturally Chain gun from Duke Nukem' 3D Energy Sword from Halo 2 Assult Rifle from Halo 1 Magnum from HL2 Blades of Chaos from God of War Double Barrled shotgun from Doom series "Grace" from Unreal 2 (am I the only one who liked that game?) Rocket Launcher from Unreal Tournament 2k3/4 Chainsaw from Doom series Redeemer and Carbine from Darkwatch Auto shotgun and Railgun from Red Faction Whip from Castlevania Mario's butt-stop Let's see what the rest of you are into.
Super charged gravity gun from Half Life 2 Magnum from Resident Evil 2 gloves from Devil May Cry guitar from Devil May Cry 3 mind powers from psi ops blades of chaos from God of War slappers from Goldeneye 64 Minigun from Timesplitters 2 Penetrator from FEAR (seriously fun) Hadouken from Street Fighter
Counter-Strike: Source....AWP, Deagle. Metal Gear Solid....Stinger Launcher Devil May Cry...Sparda Final Fantasy VII...Ultima Weapon Manhunt...Nail Gun brutal Halo 2...Energy Sword Unreal Tournament...The Redeemer Could probably think of more but those are my immediate favourites.
Gravity Gun -- HL2 Light Saber -- Jedi Knight II/Jedi Academy Flak Cannon -- UT Rocket Propelled Bullets -- UT (Chaos UT mod--official) BFG9000 --- Doom 3 Black Shark --- Descent 3 Tau Cannon --- Half-Life Freezer Gun --- Duke Nukem 3D Chainsaw --- UT Gravity Vortex --- UT
Man I forgot about a lot of those for some reason. Devil may Cry had some sweet weapons, as did FEAR (best grenades ever), and I'm just now remembering the freezer gun from DN3D. Though it's ever better when you add in the mighty boot or whatever they called it. Bust those enemy's appart once you froze them. Pretty novel for the time.
Flamethrower in Return to Castle Wolfenstein MP - AWESOME Nuke cannons in C&C Generals Defibrillator as a medic in BF2 MP Rifle grenades in Enemy Territory Shotgun from the original DOOM