The BIOS interfacing with Vista isn't the issue. However, things like memory compatibility (Gigabyte and MSI P35 boards seem to have some issues with Corsair Dominator DDR2) can come into play. If you want one, fine, but understand that early adopters sometimes have a few more bugs to work out that those who wait a few months.
Oh, and read some reviews. They're a little scarce right now, but those would give you an idea of what you're up against or if any issues would affect you.